The Fallout series didn't have to use CGI to create the Wasteland because the perfect real-life location was found

Instead of putting sand under a green screen, The Wasteland was filmed in Namibia on the Skeleton Coast. It is in this part of the desert that Kolmanskop is located, a ghost town filled with the ruins of once beautiful houses - just like the one Lucy enters in the second episode. The dry climate of the Namibian desert has preserved not only the ruins of these houses, but also their decoration and furniture. The former mining town, located in a part of the desert known as the "restricted zone", was completely abandoned by 1956, and in 2002 a private tourism company turned it into a tourist attraction.

The Wasteland is the name of what what was left of the Earth after a nuclear disaster. The first season takes place in a devastated Los Angeles known as New California. It's entirely possible we'll see the Mojave Wasteland if fan-favorite Fallout: New Vegas is chosen as the central location for Season 2.